Determining the degree of crystallization of aripiprazole during cold crystallization using thermo-optical analysis and differential scanning calorimetry

Abstract The full characteristic of the crystallization process aripiprazole crystal is given. Our research reveals that a degree crystallinity calculated from analyses data light intensity passing through sample (Thermo-Optical Analysis based on Polarized Light Microscopy—POM), Canny edge detection algorithm, and Differential Scanning Calorimetry—DSC, are in good agreement. parameters Avrami model, dimensionality growth, temperature, obtained POM DSC methods coincide. values exponent n suggest growth three-dimensional.